The defeat was Australia’s first in women’s Test cricket since 2014.
A horror start to the four-day Test came when Phoebe Litchfield was run out for a diamond duck before Ellyse Perry fell for four.
Tahlia McGrath’s half-century was the only highlight from the first innings, with Australia bowled out for 219 on the first day as Pooja Vastrakar claimed 4-53.
India then piled on 406 with Deepti Sharma top-scoring on 78 while Ash Gardner had 4-100 with the ball.
In response, Australia fared a little better on a slow wicket and looked good at 3-206.
But an awful collapse resulted in them being bowled out for 261 and India had little problem chasing the total down, finishing 2-75.
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New permanent Australian captain Alyssa Healy believed a better start on the opening day could’ve made the game interesting.
“I think if we had of batted for that full first day, that probably cost us a little bit,” she said after the Test.
“Obviously winning the toss and batting and getting bowled out on that first day and then probably leaking too many in the afternoon as well just put us on the back foot a little bit.
“I think if we’d have nudged over 300 and given ourselves an opportunity to bowl on the second day at them after a day in the field, it probably would’ve been a different prospect.
“In saying that, that’s the beauty of the game, you’ve got to execute for four days and we weren’t able to do that.”
The Test at Wankhede Stadium was Australia’s first in India since 1984, with Healy hoping for more matches to follow in the longer format.
“What an amazing experience, we got to come over here and play Test cricket. They’re not easy to win over here, we found that out,” she said.
“We’d love to play a couple more to make it really interesting but at the end of the day we probably just had one bad day on the first day and the rest of the time we showed a lot fight, so I’m proud of our effort.
“It’s our first opportunity to play red ball cricket over here so we’re learning on our feet out here and I think the way the girls continued to adapt throughout the four days was super impressive.”
Three ODIs will follow in the next week, before the tour finishes with another three T20s.